Comfort Inn

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Get a great start to your day at the Comfort Inn Poplar Bluff, MO hotel. Enjoy the friendly service and signature hot breakfast at our smoke - free hotel. We have cozy rooms and a spacious facility ready for our guests at the Comfort Inn®. Guests will be near the Highway 60 and 67 interchange, Ozark National Scenic Riverways and other nearby destinations. Come see the new look and feel at our Poplar Bluff, MO hotel. Pets are welcome! And don’t forget, you can earn rewards, including free nights and gift cards, with our Choice Privileges® Rewards program.Get a great start to your day at the Comfort Inn Poplar Bluff, MO hotel. Enjoy the friendly service and signature hot breakfast at our smoke - free hotel. We have cozy rooms and a spacious facility ready for our guests at the Comfort Inn®. Guests will be near the Highway 60 and 67 interchange, Ozark National Scenic Riverways and other nearby destinations. Come see the new look and feel at our Poplar Bluff, MO hotel. Pets are welcome! And don’t forget, you can earn rewards, including free nights and gift cards, with our Choice Privileges® Rewards program.