Jacob J. Orme, M.D., Ph.D.

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Jacob Orme, M.D., Ph.D., is a medical oncologist at Mayo Clinic Comprehensive Cancer Center in Rochester, Minnesota. Dr. Orme is a genitourinary medical oncologist and translational physician scientist who works in the clinic and the laboratory to make cancer care better for his patients. With an emphasis on advanced prostate cancer, Dr. Orme discovered the source and consequence of soluble PD-L1 in immunotherapy-resistant cancers as well as a novel biomarker "switch" in advanced highly-resistant prostate cancers. These discoveries have led to the development of multiple new therapeutics and clinical trials. Mayo Clinic is the #1 hospital in the nation, according to the U.S. News & World Report, and the Cancer Center continually ranks among the top hospitals in the U.S. for cancer. Mayo Clinic Comprehensive Cancer Center is a National Cancer Institute (NCI)-designated comprehensive cancer center.