Eli Lilly & Company

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Applied Molecular Evolution is a leader in applying directed molecular evolution to improve health care by discovering, optimizing and developing human biotherapeutics. Since its inception, AME s principal focus has been on applying its proprietary AMEsystem technology platform to the full range of protein therapeutic candidates, including antibodies, cytokines, hormones and enzymes, to develop novel human biotherapeutic candidates. Since February 2004, AME has been a wholly owned subsidiary of Eli Lilly and Company and is an integral part of Lilly s research organization. Lilly, a leading innovation-driven corporation, is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Applied Molecular Evolution maintains a location in San Diego, Calif.